Tuesday, June 18, 2019
Second-line Therapeutics for Metastatic Clear Cell Renal Carcinoma. A cancer cell is shown targeted by immune checkpoint inhibitors and antiangiogenic agents. The cancer cell is under attack by an activated T cell and the angiogenic signal for vascular growth is interrupted by inhibition of the VEGFR2 tyrosine kinase. The background shows a nephron (clear cell carcinoma originated from the proximal tubule) and a kidney with a tumor with angiogenic vessel growth.


Remembering Professor Martin Gore, 1951–2019

Tributes pour in, honoring him as ‘force of nature,’ brilliant clinician

lthough most of the 4500 or so attendees at this year’s GU ASCO meeting may not have been aware, the death of Professor Martin Gore cast a long shadow over the proceedings for those of us who knew this brilliant clinician and outstanding human being. Dr Gore, 67, one of the UK’s leading oncologists, died in January after experiencing total organ failure following a yellow fever vaccination, an extremely rare complication.
A report in the Journal of Travel Medicine found that between 2007 and 2013, there were just under four cases of serious adverse effects from the vaccine per 100,000 doses. This increased to 6.5 per 100,000 for those aged between 60 and 69, and 10.3 per 100,000 for those aged 70 and above. The vaccination is recommended for anyone visiting Sub-Saharan Africa, South and Central America, and the Caribbean.
Dr Gore, who inspired generations of physicians, was a professor at the Institute of Cancer Research and former Medical Director of the Royal Marsden Hospital, London. Prof Mel Greaves, from The Institute of Cancer Research, said: “Martin was  Read More

CURRENT ISSUE Volume 17, Number 1



  • Essential Peer-Reviewed Reading in Kidney Cancer
    Long-term responders (LTRs) are defined by at least 18 months of response to sunitinib in metastatic clear-cell renal cell carcinoma (ccRCC). The phenotype of these […]